All specimens are evaluated for white blood cell (WBC) count with differential via automated cell count (all counts >3,000 cells confirmed with manual count). If final reported WBC count is >3,000 cells/μL or neutrophil is >70%, specimens are reflexed to Synovasure Alpha Defensin for NSA (alpha defensin and lactate), Synovasure Microbial Identification and Fluid Culture.
Synovasure Alpha Defensin for NSA
Laboratory-developed test (LDT) for alpha defensin biomarker and lactate. The alpha defensin biomarker demonstrates high level of accuracy in identifying infection1* and is unaffected by:
- Prior Antibiotic Administration2,3
- History of Inflammatory Conditions2,4
- Type/Virulence of Organism2,5
* *的αdefensin验证和性能based on cases of PJI and has not been defined for NSA due to no comparative “Gold Standard” criterion.
Synovasure Microbial Identification
Novel, antigen bead-based test for early identification of potential infection causing organisms including:
- Staphylococcusspecies
- Enterococcusspecies
- Candidaspecies
- C. acnes
Synovasure Microbial Identification is also capable of identifying more than 54% of culture-negative PJI specimens6.
Fluid Culture
Aerobic and anaerobic culture performed to aid in the diagnosis and treatment of infection.
All fluid cultures are held for seven (7) days.